公表論文

Reviews

  1. MDR-ABC Transporters - Biomarkers in Rheumatoid Arthritis
  2. Márki-Zay J, Tauberné Jakab K, Szerémy P, Krajcsi P. Clinical and Experimental Rheumatology 2013 May 27. [Epub ahead of print]
  3. Efflux transporters in the blood-brain interfaces - in vitro and in vivo methods and correlations.
  4. Krajcsi P, Jani M, Tóth B, Erdő F, Kis E, Beéry E, Sziráki I. EXPERT OPIN DRUG METAB TOXICOL. 2012 Apr;8(4):419-431.
  5. ABCC2/Abcc2 - a multispecific transporter with dominant excretory functions
  6. K. Jemnitz, K. Heredi-Szabo, L Vereczkey and P. Krajcsi
    Drug Metab Rev. 2010 Aug;42(3):402-36.
  7. Potentiation of MRP2/Mrp2-mediated Estradiol-17β-Glucuronide Transport by Drugs - A Concise Review
  8. K. Herédi Szabó, K. Jemnitz, E. Kis, E. Ioja, J. Jánossy, L. Vereczkey and P. Krajcsi
    Chem Biodivers. 2009 Nov;6(11):1970-4.
  9. Interaction of macrocyclic lactones with the multidrug transporters: the bases of the pharmacokinetics of lipid-like drugs
  10. A. Lespine, J. Dupuy, C. Borin, M. Alvinerie, C. Comera, T. Nagy, P. Krajcsi and S. Orlowski
    Curr Drug Metab. 2009 Mar;10(3):272-88.
  11. Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays
  12. Csilla Hegedűs, Gergely Szakács, László Homolya, Tamás I. Orbán, Ágnes Telbisz, Márton Jani and Balázs Sarkadi
    Adv Drug Deliv Rev. 2009 Jan 31;61(1):47-56. Epub 2008 Dec 24.
  13. Utilization of membrane vesicle preparations to study drug-ABC transporter interactions
  14. Glavinas H, Méhn D, Jani M, Oosterhuis B, Herédi-Szabó K, Krajcsi P
    Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):721-32.
  15. The role of ABC transporters in drug resistance, metabolism and toxicity
  16. Glavinas H, Krajcsi P, Cserepes J, Sarkadi B
    Curr Drug Deliv. 2004 Jan;1(1):27-42.

Role of transporters in drug ADME

  1. Chlorothiazide is a substrate for the human uptake transporters OAT1 and OAT3.
  2. Juhász V, Beéry E, Nagy Z, Bui A, Molnár E, Zolnerciks JK, Magnan R, Jani M, Krajcsi P. J Pharm Sci. 2013 May;102(5):1683-7
  3. A P-gp vesicular transport inhibition assay - Optimization and validation for drug-drug interaction testing.
  4. Herédi-Szabó K, Palm JE, Andersson TB, Pál A, Méhn D, Beéry E, Jakab KT, Jani M, Krajcsi P. Eur J Pharm Sci. 2013 May 15
  5. Application of Receiver Operating Characteristic (ROC) Analysis to Refine the Prediction of Potential Digoxin Drug Interactions.
  6. Ellens H, Deng S, Coleman J, Bentz J, Taub ME, Ragueneau-Majlessi I, Chung S, Heredi-Szabo K, Neuhof S, Palm JE, Balimane P, Zhang L, Jamei M, Hanna IH, O’Connor M, Bednarczyk D, Forsgard M, Chu X, Funk C, Guo A, Hillgren KM, Li L, Pak A, Perloff E, Rajaraman G, Salphati L, Taur J, Weitz D, Wortelboer H, Xia C, Xiao G, Yamagata T, Lee CA. Drug Metab Dispos. 2013 Apr 25
  7. Interactions of bilastine, a new oral H1 antihistamine, with human transporter systems
  8. Lucero ML, Gonzalo A, Ganza A, Leal N, Soengas I, Ioja E, Gedey S, Jahic M, Bednarczyk D. Drug Chem Toxicol. 2012 Jun;35 Suppl 1:8-17.
  9. ABCG2 modulates chlorothiazide permeability in vitro-characterization of its interactions.
  10. Erzsébet Beéry, Zsuzsanna Rajnai, Tibor Abonyi, Ildikó Makai, Száva Bánsághy, Franciska Erdő, István Sziráki, Emese Kis, Márton Jani, Gábor K Tóth, Peter Krajcsi Drug Metab Pharmacokinet. 2011 Nov 29.
  11. Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells
  12. Walter Brand, Berend Oosterhuis, Peter Krajcsi, Denis Barron, Fabiola Dionisi, Peter J. van Bladeren, Ivonne M.C.M. Rietjens, Gary Williamson BIOPHARMACEUTICS & DRUG DISPOSITION 2011 Dec;32(9):530-5.
  13. Specific inhibition of the ABCG2 transporter could improve the efficacy of photodynamic therapy
  14. Attila Bebes, Tünde Nagy, Zsuzsanna Bata-Csörg, Lajos Kemény, Attila Dobozy, Márta Széll J Photochem Photobiol B. 2011 Nov 3;105(2):162-6. Epub 2011 Aug 23.
  15. Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo Evidences
  16. Li Zhang, Chenrui Li, Ge Lin, Peter Krajcsi, Zhong Zuo AAPS J. 2011 Sep;13(3):378-89. Epub 2011 May 24.
  17. Digoxin is not a Substrate for Organic Anion Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a Substrate for a Sodium Dependent Transporter Expressed in HEK293 Cells
  18. Taub ME, Mease KM, Sane RS, Watson CA, Chen L, Ellens H, Hirakawa BP, Reyner EL, Jani M, Lee CA. Drug Metab Dispos. 2011 Aug 17.
  19. Quinidine as an ABCB1 Probe for Testing Drug Interactions at the Blood-Brain Barrier: An In Vitro In Vivo Correlation Study
  20. Sziráki I, Erdo F, Beéry E, Molnár PM, Fazakas C, Wilhelm I, Makai I, Kis E, Herédi-Szabó K, Abonyi T, Krizbai I, Tóth GK, Krajcsi P. J Biomol Screen. 2011 Aug 10.
  21. Calcein assay: a high-throughput method to assess P-gp inhibition
  22. Glavinas H, von Richter O, Vojnits K, Mehn D, Wilhelm I, Nagy T, Janossy J, Krizbai I, Couraud P, Krajcsi P. Xenobiotica. 2011 Aug;41(8):712-9. Epub 2011 Jun 9.
  23. Comparison of 3 Assay Systems Using a Common Probe Substrate, Calcein AM, for Studying P-gp Using a Selected Set of Compounds
  24. Szerémy P, Pál A, Méhn D, Tóth B, Fülöp F, Krajcsi P, Herédi-Szabó K.
    J Biomol Screen. 2010 Nov 5.
  25. ATP-Binding Cassette B1 Transports Seliciclib (R-Roscovitine), a Cyclin-Dependent Kinase Inhibitor
  26. Zsuzsanna Rajnai, Dóra Méhn, Erzsébet Beéry, Alper Okyar, Márton Jani, Gábor K. Tóth, Ferenc Fülöp, Francis Lévi and Peter Krajcsi
    Drug Metab Dispos. 2010 Nov;38(11):2000-6. Epub 2010 Aug 10.
  27. MRP2-mediated E2-17βG transport potentiation: in vitro - in vivo correlation and species specificity
  28. K. Heredi-Szabo, H. Glavinas, E. Kis, D. Méhn, G. Báthori, Z. Veres, L. Kóbori, O. von Richter, K. Jemnitz and P. Krajcsi
    Drug Metab Dispos. 2009 Apr;37(4):794-801. Epub 2008 Dec 31.
  29. Kinetic characterization of sulfasalazine transport by human ABCG2 (BCRP)
  30. M. Jani, P. Szabó, E. Kis, É. Molnár, H. Glavinas, P. Krajcsi
    Biol Pharm Bull. 2009 Mar;32(3):497-9.
  31. Leflunomide and A771726, its metabolite are high affinity substrates of BCRP - implications for drug resistance
  32. Kis E, Nagy T, Jani M, Molnár E, Jánossy J, Ujhelly O, Német K, Herédi-Szabó K, Krajcsi P
    Ann Rheum Dis. 2009 Jul;68(7):1201-7. Epub 2008 Apr 8.
  33. A novel screening strategy to identify ABCB1 substrates and inhibitors
  34. O. von Richter, H. Glavinas, P. Krajcsi, S. Liehner, B. Siewert, K. Zech
    Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. Epub 2008 Aug 29.
  35. Characterization of 5(6)-carboxy-2,‘7’-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4
  36. Heredi-Szabo K, Kis E, Molnar E, Gyorfi A, Krajcsi P
    J Biomol Screen. 2008 Apr;13(4):295-301. Epub 2008 Mar 18.
  37. In vitro methods suitable for the prediction of drug and ABC transporter, especially ABCG2 interactions
  38. Pál A, Kis E, Méhn D, Glavinas H, Nagy T, Mészáros P, Báthori G, Krajcsi P, Falkay G
    Acta Pharm Hung. 2007;77(4):205-16.
  39. Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes
  40. Lengyel G, Veres Z, Tugyi R, Vereczkey L, Molnár T, Glavinas H, Krajcsi P, Jemnitz K.
    Hepatol Res. 2008 Mar;38(3):300-9. Epub 2007 Aug 29.
  41. ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions
  42. Glavinas H, Kis E, Pál A, Kovács R, Jani M, Vági E, Molnár E, Bánsághi S, Kele Z, Janáki T, Báthori G, von Richter O, Koomen GJ, Krajcsi P
    Drug Metab Dispos. 2007 Sep;35(9):1533-42. Epub 2007 May 30.
  43. Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2
  44. Pál A, Méhn D, Molnár E, Gedey S, Mészáros P, Nagy T, Glavinas H, Janáki T, von Richter O, Báthori G, Szente L, Krajcsi P
    J Pharmacol Exp Ther. 2007 Jun;321(3):1085-94. Epub 2007 Mar 8.
  45. Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)
  46. Schmitt U, Abou El-Ela A, Guo LJ, Glavinas H, Krajcsi P, Baron JM, Tillmann C, Hiemke C, Langguth P, Härtter S
    J Neural Transm. 2006 Jul;113(7):787-801. Epub 2005 Oct 27.
  47. Comparative analysis of human multidrug resistance associated protein 2 (MRP2) and rat MRP2
  48. Krajcsi P, Glavinas H, Kis E, Kovács R, Pal A
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 25S1 (2005) S1–S226
  49. Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells
  50. Özvegy Cs, Litman T, Szakács G, Nagy Z, Bates S, Váradi A, and Sarkadi B
    Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7.
  51. Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization
  52. Cserepes J, Szentpetery Z, Seres L, Ozvegy-Laczka C, Langmann T, Schmitz G, Glavinas H, Klein I, Homolya L, Varadi A, Sarkadi B, Elkind NB
    Biochem Biophys Res Commun. 2004 Jul 30;320(3):860-7.

Role of transporters in drug toxicity

  1. BSEP inhibition – in vitro screens to assess cholestatic potential of drugs.
  2. Emese Kis, Enikő Ioja, Zsuzsa Rajnai, Márton Jani, Dóra Méhn, Krisztina Herédi-Szabó, Peter Krajcsi Toxicol In Vitro. 2011 Nov 18.
  3. Effect of membrane cholesterol on BSEP/Bsep activity - species specificity studies for substrates and inhibitors
  4. E. Kis, E. Ioja, T. Nagy, K. Herédi-Szabó and P. Krajcsi
    Drug Metab Dispos. 2009 Sep;37(9):1878-86. Epub 2009 Jun 11.
  5. Mouse Bsep ATPase assay: a nonradioactive tool for assessment of the cholestatic potential of drugs
  6. E. Kis, Z. Rajnai, E. Ioja, K. Herédi-Szabó, T. Nagy, D. Méhn and P. Krajcsi
    J Biomol Screen. 2009 Jan;14(1):10-5. Epub 2008 Nov 21.

Role of transporters in bioavailability of nutraceuticals and in risk assessement of environmental toxicants

  1. Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters
  2. Chi C. Wong, Denis Barron, Caroline Orfila, Fabiola Dionisi, Peter Krajcsi and Gary Williamson MOL NUTR FOOD RES. 2011 Jul;55(7):979-88. doi: 10.1002/mnfr.201000652. Epub 2011 Apr 29.
  3. Ivermectin interacts with human ABCG2.
  4. M. Jani, I. Makai, E. Kis, P. Szabó, T. Nagy, P. Krajcsi and A. Lespine J PHARM SCI, J Pharm Sci. 2011 Jan;100(1):94-7                                          
  5. Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1
  6. Dreiseitel A, Oosterhuis B, Vukman KV, Schreier P, Oehme A, Locher S, Hajak G, Sand PG
    Br J Pharmacol. 2009 Dec;158(8):1942-50.
  7. Specific interactions of chloroacetanilide herbicides with human ABC transporter proteins
  8. Oosterhuis B, Vukman K, Vági E, Glavinas H, Jablonkai I, Krajcsi P
    Toxicology. 2008 Jun 3;248(1):45-51. Epub 2008 Mar 14.
  9. Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2)
  10. Williamson G, Aeberli I, Miguet L, Zhang Z, Sanchez MB, Crespy V, Barron D, Needs P, Kroon PA, Glavinas H, Krajcsi P, Grigorov M
    Drug Metab Dispos. 2007 Aug;35(8):1262-8. Epub 2007 May 3.
  11. Mechanistic study on the intestinal absorption and disposition of baicalein
  12. Zhang L, Lin G, Kovács B, Jani M, Krajcsi P, Zuo Z
    Eur J Pharm Sci. 2007 Jul;31(3-4):221-31. Epub 2007 Apr 9.
  13. Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3)
  14. Lespine A, Dupuy J, Orlowski S, Nagy T, Glavinas H, Krajcsi P, Alvinerie M
    Chem Biol Interact. 2006 Feb 25;159(3):169-79. Epub 2005 Dec 27.

Miscellaneous

  1. The Use of Microdialysis Techniques in Mice to Study P-gp Function at the Blood-Brain Barrier
  2. Sziráki I, Erdő F, Trampus P, Sike M, Molnár PM, Rajnai Z, Molnár J, Wilhelm I, Fazakas C, Kis E, Krizbai I, Krajcsi P. J BIOMOL SCREEN.  2013 Apr; 18 (4): 430 - 440.
  3. Drug-transporter interaction testing in drug discovery and development
  4. Krajcsi P. WORLD J PHARMACOL 2013, 2(1):35-46.
  5. Synthesis and ABCG2-Inhitory Activity of Novel Fumitremorgin C Analogs Specificity and Structure Activity Correlations.
  6. Szolomajer-Csikós O, Beéry E, Kósa L, Rajnai Z, Jani M, Hetényi A, Jakab KT, Krajcsi P, Tóth GK. MED CHEM. 2012 AUG 17.
  7. Verification of brain penetration of the unbound fraction of a novel HER2/EGFR
  8. Franciska Erdo, Justin Gordon, Jing-Tao Wu, István Sziráki BRAIN RES BULL. 2012 Mar 10;87(4-5):413-9. Epub 2012 Jan 9.
  9. The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related
  10. Attila Bebes, Kornélia Kis, Tünde Nagy, Anita Kurunczi, Hilda Polyánka, Zsuzsanna Bata-Csörgő, Lajos Kemény, Attila Dobozy, Márta Széll ARCH DERMATOL RES. 2012 Jan;304(1):57-63. Epub 2011 Sep 16.
  11. Characterisation of a GroEL Single-Ring Mutant that Supports Growth of Escherichia coli and Has GroES-Dependent ATPase Activity
  12. Kovács E, Sun Z, Liu H, Scott DJ, Karsisiotis AI, Clarke AR, Burston SG, Lund PA.
    J Mol Biol. 2010 Mar 12;396(5):1271-83. Epub 2009 Dec 16.
  13. Pentoxifylline and its major oxidative metabolites exhibit different pharmacological properties
  14. Fantin M, Quintieri L, Kúsz E, Kis E, Glavinas H, Floreani M, Padrini R, Duda E, Vizler C
    Eur J Pharmacol. 2006 Mar 27;535(1-3):301-9.

Book chapters

  1. ABC transporters in the blood-brain barrier - relevance in stroke therapy in Recent advances and new strategies in stroke research
  2. In: Recent advances and new strategies in stroke research (editors: Z Nagy, F Erdo)
    M. Bollók, J. Jánossy and P. Krajcsi
    2008, Transworld Research Network, Kerala, pp167-190
  3. Microdialysis techniques in stroke research: Experimental and clinical aspects
  4. In: Recent advances and new strategies in stroke research (editors: Z Nagy, F Erdo)
    F Erdő, F Andrási and I Sziráki
    2008, Transworld Research Network, Kerala, pp291-317

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